![]() Functional dead space: ventilated lung parts, which are not perfused (~0 for healthy person next lecture).Anatomical dead space: airways (nose→bronchioli).Consequences for alveolar gas pressures and/or breathing work: CO2 retention.Volume must be limited (in relation to TV): standards!.Snorkel volume increases physiological dead space.If TV increased from 0.5 to 0.7 L, as part of will be smaller and vice versa.Clinical relevance: Bronchiectasis, ventilation-perfusion disturbances (obstruction by tumour, emboli, etc.).Single breath method (Christian Bohr, ~1900).Measuring Dead Space Despopoulos & Silbernagl 2003 How can physiological dead space be determined?.How big is ventilation of physiological dead space at TV (“inefficiency”)? ¼- ⅓.In a healthy person, “dead space” is called physiological dead space.Example: Breathing frequency (12 bpm) and tidal volume (TV 0.5 L).Total ventilation: (Volume per minute).Global Ventilation (over whole lung) Total Pulmonary Ventilation = Physiological Dead Space Ventilation+ Alveolar Ventilation Axis along bottom indicates distance from nose. ![]() Factors determining uneven pulmonary ventilation.Total ventilation, dead space ventilation.Physiological dead space and its elements.illustrate how uneven ventilation of lung tissue can arise.recognise that RAW and compliance determine the speed of gas exchange in alveoli and.explain how ventilation determines partial pressure of CO2.discuss the components of physiological dead space.outline different components of ventilation.THE AUSTRALIAN NATIONAL UNIVERSITY Alveolar Ventilation and Factors Influencing ItChristian StrickerAssociate Professor for Systems PhysiologyANUMS/JCSMR - At the end of this lecture students should be able to
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